STRATEGIES FOR BUSINESS IN VIRTUAL WORLDS: CASE STUDIES IN SECOND LIFE

Second Life (SL) is an immersive, virtual 3D social interaction environment developed by Linden Lab where business including monetary transactions can take place. SL is a virtual world that also provides support for virtual organisations; a group of individuals whose members and resources may be dispersed geographically, but who function as a coherent unit through the use of cyber infrastructure. In this paper, we use qualitative and quantitative methodologies to analyse and understand a range of business strategies and activities in SL. We discuss key economic elements in SL and classify firms from the Forbes Global Top 500 companies which have a presence and who operate in B-B, B-C, C-C, and G-C spaces within SL. We develop business cases for three well known firms active in SL, namely IBM, Coca Cola, and Nissan, as a means to explore correlative relationships and potential business strategies future development

Right ventricular exclusion for hepatocellular carcinoma metastatic to the heart

We used for the first time a right ventricular exclusion procedure for the treatment of hepatocellular carcinoma metastatic to the right ventricle. Our case report shows that this surgical option can be effective as rescue therapy for right ventricular outflow tract obstruction secondary to myocardial metastasis in critically ill patients. Most notably, this technique can prevent inadvertent dislodgement of tumor cells

Performances des Réseaux LTE

Poussé par la demande croissante de services à haut débit sans fil, Long Term Evolution (LTE) a émergé comme une solution prometteuse pour les communications mobiles. Dans plusieurs pays à travers le monde, la mise en oeuvre de LTE est en train de se développer. LTE offre une architecture tout-IP qui fournit des débits élevés et permet une prise en charge efficace des applications de type multimédia. LTE est spécifié par le 3GPP ; cette technologie fournit une architecture capable de mettre en place des mécanismes pour traiter des classes de trafic hétérogènes comme la voix, la vidéo, les transferts de fichier, les courriers électroniques, etc. Ces classes de flux hétérogènes peuvent être gérées en fonction de la qualité de service requise mais aussi de la qualité des canaux et des conditions environnementales qui peuvent varier considérablement sur une courte échelle de temps. Les standards du 3GPP ne spécifient pas l algorithmique de l allocation des ressources du réseau d accès, dont l importance est grande pour garantir performance et qualité de service (QoS). Dans cette thèse, nous nous focalisons plus spécifiquement sur la QoS de LTE sur la voie descendante. Nous nous concentrons alors sur la gestion des ressources et l ordonnancement sur l interface radio des réseaux d accès. Dans une première partie, nous nous sommes intéressés à des contextes de macro-cellules. Le premier mécanisme proposé pour l allocation des ressources combine une méthode de jetons virtuels et des ordonnanceurs opportunistes. Les performances obtenues sont très bonnes mais n assurent pas une très bonne équité. Notre seconde proposition repose sur la théorie des jeux, et plus spécifiquement sur la valeur de Shapley, pour atteindre un haut niveau d équité entre les différentes classes de services au détriment de la qualité de service. Cela nous a poussé, dans un troisième mécanisme, à combiner les deux schémas. La deuxième partie de la thèse est consacrée aux femto-cellules (ou femtocells) qui offrent des compléments de couverture appréciables. La difficulté consiste alors à étudier et à minimiser les interférences. Notre premier mécanisme d atténuation des interférences est fondé sur le contrôle de la puissance de transmission. Il fonctionne en utilisant la théorie des jeux non coopératifs. On effectue une négociation constante entre le débit et les interférences pour trouver un niveau optimal de puissance d émission. Le second mécanisme est centralisé et utilise une approche de division de la bande passante afin d obliger les femtocells à ne pas utiliser les mêmes sous-bandes évitant ainsi les interférences. Le partage de bande passante et l allocation sont effectués en utilisant sur la théorie des jeux (valeur de Shapley) et en tenant compte du type d application. Ce schéma réduit les interférences considérablement. Tous les mécanismes proposés ont été testés et évalués dans un environnement de simulation en utilisant l outil LTE-Sim au développement duquel nous avons contribué.Driven by the growing demand for high-speed broadband wireless services, Long term Evolution (LTE) technology has emerged as a competitive alternative to mobile communications solution. In several countries around the world, the implementation of LTE has started. LTE offers an IP-based framework that provides high data rates for multimedia applications. Moreover, based on the 3GPP specifications, the technology provides a set of built in mechanisms to support heterogeneous classes of traffic including data, voice and video, etc. Supporting heterogeneous classes of services means that the traffic is highly diverse and has distinct QoS parameters, channel and environmental conditions may vary dramatically on a short time scale. The 3GPP specifications leave unstandardized the resource management and scheduling mechanisms which are crucial components to guarantee the QoS performance for the services. In this thesis, we evaluate the performance and QoS in LTE technology. Moreover, our research addresses the resource management and scheduling issues on the wireless interface. In fact, after surveying, classifying and comparing different scheduling mechanisms, we propose three QoS mechanisms for resource allocation in macrocell scenarios focused on real time services and two mechanisms for interference mitigation in femtocell scenarios taking into account the QoS of real time services. Our first proposed mechanism for resource allocation in macrocell scenarios combines the well known virtual token (or token buckets) method with opportunistic schedulers, our second scheme utilizes game theory, specifically the Shapley value in order to achieve a higher fairness level among classes of services and our third mechanism combines the first and the second proposed schemes. Our first mechanism for interference mitigation in femtocell scenarios is power control based and works by using non cooperative games. It performs a constant bargain between throughput and SINR to find out the optimal transmit power level. The second mechanism is centralised, it uses a bandwidth division approach in order to not use the same subbands to avoid interference. The bandwidth division and assignation is performed based on game theory (Shapley value) taking into account the application bitrate . This scheme reduces interference considerably and shows an improvement compared to other bandwidth division schemes. All proposed mechanism are performed in a LTE simulation environment. several constraints such as throughput, Packet Loss Ratio, delay, fairness index, SINR are used to evaluate the efficiency of our schemesTOULOUSE-INP (315552154) / SudocSudocFranceF

PI3K/Akt pathway: a potential therapeutic target for chronic pain

Chronic pain is among the most disabling and costly disorders, with prevalence ranging from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory due to our poor understanding of its mechanisms. Thus, novel therapeutic targets need to be found in order to improve these patients' quality of life. PI3K and its downstream Akt are widely expressed in the spinal cord, particularly in the laminae I-IV of the dorsal horn, where nociceptive C and Aδ fibers of primary afferents principally terminate. Recent studies have demonstrated their critical roles in the development and maintenance of chronic pain. In this review, we summarized the roles and mechanisms of PI3K/Akt pathway in the progression of chronic pain through sciatic nerve injury, diabetic neuropathy, spinal cord injury, bone cancer, opioid tolerance, or opioid-induced hyperalgesia

The role of spinal GABAB receptors in cancer-induced bone pain in rats

Cancer-induced bone pain (CIBP) remains a major challenge in advanced cancer patients due to our lack of understanding of its mechanisms. Previous studies have demonstrated the vital role of GABAB receptors (GABABRs) in regulating nociception and various neuropathic pain models have shown diminished activity of GABABRs. However, the role of spinal GABABRs in CIBP remains largely unknown. In this study, we investigated the specific cellular mechanisms of GABABRs in the development and maintenance of CIBP in rats. Our behavioral results show that both acute and chronic intrathecal treatment with baclofen, a GABABR agonist, significantly attenuated CIBP-induced mechanical allodynia and ambulatory pain. The expression levels of GABABRs were significantly decreased in a time-dependent manner and colocalized mostly with neuron and a minority with astrocyte and microglia. Chronic treatment with baclofen restored the expression of GABABRs and markedly inhibited the activation of cAMP-dependent protein kinase (PKA) and the cAMP-response element-binding protein (CREB) signaling pathway

Hospital Mortality of Septic Acute Kidney Injury Requiring Renal Replacement Therapy in the Postoperative Elderly

SummaryBackgroundSeptic acute kidney injury (AKI) is a common complication in intensive care units (ICU), it and portends a higher risk of morbidity and death than nonseptic AKI. However, its outcome and prognostic factors among elderly postoperative patients remain unknown. We aimed to determine the risk factors and predictors of mortality among postoperative elderly patients (≥ 65 years) with septic AKI requiring acute dialysis.MethodsThe study protocol was based on that of a clinical cohort study of renal failure patients in the database of the National Taiwan University Surgical ICU Acute Renal Failure (NSARF) Study Group. From January 2002 to July 2009, patients (aged > 18 years) with postoperative AKI requiring renal replacement therapy (RRT) were recruited for this study. Each case of septic AKI before operation was identified and patients with end-stage renal disease were excluded.ResultsA total of 292 postoperative patients with septic AKI requiring dialysis were identified during the study period. The mean (SD) age was 65.9 (11.9) years and 68.2% were men. Abdominal surgery was the most common type of surgery (42.8%), followed by cardiovascular (28.8%) and chest surgery (15.4%). The most common indications for RRT in this study cohort were azotemia in 223 patients (76.4%) and fluid overload in 62 patients (21.2%); 92 (31.5%) patients had one indication, 170 (58.2%) had two indications, and 30 (10.3%) had more than three indications. The elderly patients (those ≥ 65 years) had anemia, underwent abdominal surgery, and received dialysis for fluid overload more frequently than the young adults. By contrast, the young adults were more likely to present with shock requiring vasopressor use and have abnormal liver functions. In the elderly subgroup, the outcome was found to be associated with mechanical ventilator use, but not with disease severity, comorbidities, types of surgery and the indication for dialysis.ConclusionsThe hospital mortality of postoperative elderly patients with septic AKI was more than 60% and was not affected by age. Mechanical ventilator use was the major risk factor and prognostic factor for elderly patients in this clinical setting

An integrated multicomponent care model for men affected by prostate cancer: A feasibility study of TrueNTH Australia

Objective: To evaluate the feasibility of implementing an integrated multicomponent survivorship care model for men affected by prostate cancer. Methods: Using a single arm prospective cohort study design, men with prostate cancer were recruited from two regional public hospitals in Australia for a 6-months program that provided information and decision support, exercise and nutrition management, specialised clinical support, and practical support through localised and central care coordination. Carers of the men were also invited to the program. Data were collected from multiple sources to evaluate: (1) recruitment capability and participant characteristics; (2) appropriateness and feasibility of delivering the specific intervention components using an electronic care management tool; and (3) suitability of data collection procedures and proposed outcome measures. Results: Of the 105 eligible men, 51 (consent rate 49%) participated in the program. Of the 31 carers nominated by the men, 13 consented (consent rate 42%). All carers and 50 (98%) men completed the program. Most (92%) men were newly diagnosed with localised prostate cancer. All men attended initial screening and assessment for supportive care needs; a total of 838 episodes of contact/consultation were made by the intervention team either in person (9%) or remotely (91%). The intervention was implemented as proposed with no adverse events. The proposed outcome measures and evaluation procedures were found to be appropriate. Conclusions: Our results support the feasibility of implementing this integrated multicomponent care model for men affected by prostate cancer

Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies

Hepatitis C virus (HCV) infection is a major cause of liver disease and hepatocellular carcinoma. Glycan shielding has been proposed to be a mechanism by which HCV masks broadly neutralizing epitopes on its viral glycoproteins. However, the role of altered glycosylation in HCV resistance to broadly neutralizing antibodies is not fully understood. Here, we have generated potent HCV neutralizing antibodies hu5B3.v3 and MRCT10.v362 that, similar to the previously described AP33 and HCV1, bind to a highly conserved linear epitope on E2. We utilize a combination of in vitro resistance selections using the cell culture infectious HCV and structural analyses to identify mechanisms of HCV resistance to hu5B3.v3 and MRCT10.v362. Ultra deep sequencing from in vitro HCV resistance selection studies identified resistance mutations at asparagine N417 (N417S, N417T and N417G) as early as 5 days post treatment. Comparison of the glycosylation status of soluble versions of the E2 glycoprotein containing the respective resistance mutations revealed a glycosylation shift from N417 to N415 in the N417S and N417T E2 proteins. The N417G E2 variant was glycosylated neither at residue 415 nor at residue 417 and remained sensitive to MRCT10.v362. Structural analyses of the E2 epitope bound to hu5B3.v3 Fab and MRCT10.v362 Fab using X-ray crystallography confirmed that residue N415 is buried within the antibody–peptide interface. Thus, in addition to previously described mutations at N415 that abrogate the β-hairpin structure of this E2 linear epitope, we identify a second escape mechanism, termed glycan shifting, that decreases the efficacy of broadly neutralizing HCV antibodies